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Posted: Mon May 21, 2007 3:21 pm
by seraphima
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Everybody has a series of haemoglobin genes. These are normal so not considered mutant.

Haemoglobin molecules usually consist of four sub-units of haemoglobin. The forms that are produced vary during the lifecycle.


The embryo produces haemoglobins alpha, gamma and epsilon, while the later fetus produces mainly alpha and gamma haemoglobins. This form has a higher affinity for oxygen than adult haemoglobin, allowing the fetal blood to "steal" oxgen from the mother's blood.
Adults usually produce mainly alpha and beta haemoglobins.
The delta form is less common and therefore not very important.

Mutant forms of haemoglobin are those which have different oxygen carrying abilities that are detrimental, for example haemoglobin S, which causes sickle cell anaemia.

Epogen is an artificial form (created using recombinant DNA- inserting the human gene into mammalian cells) of the hormone epoetin alfa, which stimulates production of red blood cells by the bone marrow. It is given to patients undergoing cancer therapy or with kidney failure. Iron supplements are sometimes recommended alongside epogen.

Epogen is sometimes used when blood needs to be harvested, for example for autologous blood transfusion during an operation.

There are safety risks with epogen, and doctors in the US were recently criticised for overusing this type of medicine.

Epogen may also be used illegally in sports, but is dangerous when used in otherwise healthy people. There are reports of deaths, usually when the athlete is lying down and asleep, caused by the thickening of the blood with extra red blood cells.

The presence/absence of something in blood makes me think of the rhesus factor.

Posted: Mon May 21, 2007 3:41 pm
by susanne_buit
seraphima wrote: The presence/absence of something in blood makes me think of the rhesus factor.
Yeah, but isn“t the rhesus factor present on every red bloodcell? Since we're talking about pg/mL, which is a really low concentration.. so I'm thinking it's some sort of hormone or something.

Posted: Mon May 21, 2007 5:56 pm
by cbizzle44
susanne_buit wrote:
I dont know, maybe she doesn't have a bad trait, and has all good traits? To be honest, we cannot truly know until we see Bree's medical report. (It sucks that it is in CA. Though it probably will say trait positive, it might have more clues. Maybe it is filled out more than Jules's, b/c Bree would be more important if she could do the ceremony. Ya never know.)

Daniel said in the Chat that they're heading back to Jonas' house, so they could try the same thing there and find her file! Hope that gives a little more information...
i'm torn now. i want them to FIND BREE. but i also now want them to go find bree's file. oh dear.
what a dilemma.

Posted: Mon May 21, 2007 8:52 pm
by ApotheosisAZ
I just got off the phone with a friend who is a hospital lab tech. She also does phlebotomy (draws blood for medical tests.)

Her initial reaction when I explained the picograms per milliliter quantity was the possible presence of a trace element. She had assumed that I was talking about a poison.

I explained that we were looking for a trait. She then said it was most likely a hormone. She told me that 15.2 picograms per milliliter is about the same ratio as a grain of sand in an Olympic swimming pool. She promised to look into it at work tomorrow.

Posted: Mon May 21, 2007 10:41 pm
by Spades
Oh, wow, Apo. Damn, didnt know anyone had connections like that. Good job.

How long until your friend can get back with you? I know they said tommorow, but hospitals can get quite busy.

Or do they just work in a lab? Either way...

Posted: Tue May 22, 2007 2:51 pm
by Languorous Lass
ApotheosisAZ wrote:She told me that 15.2 picograms per milliliter is about the same ratio as a grain of sand in an Olympic swimming pool.
:shock:

And that can be detected? Wow.