Lonelygirl15

Awesome! Great job, kellylen. Never doubted you for a minute.

Props to a fellow scientist (albeit in a field much more relevant than mine at the moment).

The Bree Solution (that sounds REALLY important )
Objectives:
How to transform Bree from TRAIT: POSITIVE to TRAIT: NEGATIVE

Given Facts:
1) Bree's blood contains a special ribozyme mutated and unique only to her
2) The gene for said ribozyme has a regular hyper mutation that changes with every generation
3) A non-functioning mutated ribozyme exists and manifests differently in every Hymn of One girl
4) This portion still functions but you cannot blend it because the complimentary strands of RNA won't combine

Theoretical Solution
1) Block the ribozyme in question by obtaining a sample of that same ribozyme in order to copy it
2) Create complimentary strand of RNA
3) Q.E.D. strand will bind to ribozyme and occlude its copy

Practical Solution
1) Obtain blood sample of Bree
2) Synthesize complimentary strand of RNA
3) Inject Bree with this complementary strand
4) Q.E.D. ribozymes blocked will be rendered defunctional

Intended Results
1) Once synthesized and injected into Bree she'll become trait negative
2) Additional consequences (if any) - TBD

______ Reference Points
The steps concerning ribozyme function
RNAse P related -tRNA cleavage
Splicosome related - intron/exon splicing
______related - telomere synthesis
GlmS ribozyme related - fructose 6-phosphate pathway

so, we're just missing those two words, right?

a_little_nachtmusik wrote:I'm almost done with the whole thing you guys. Give me half an hour tops.

lol its pretty much done. the solution has been posted to spencer. it is the tentative answer. from which he will get the rough idea from if some of it doesnt make sense. and if not i wonder what kind of scientist he is

Well, here's where I am right now...

I'll go back and add some of what you guys have:

Meepers has some more changes suggested on the comments if anyone wants to scope them out.

Great job, everybody!

the solution has been posted to spencer.

Except that I think some of us disagree with a couple of the words in that solution.

where are they going to get a copy of "that same ribosome"?

[/quote]

Just bringing it forward...

kellylen wrote:

a_little_nachtmusik wrote:I'm almost done with the whole thing you guys. Give me half an hour tops.

lol its pretty much done. the solution has been posted to spencer. it is the tentative answer. from which he will get the rough idea from if some of it doesnt make sense. and if not i wonder what kind of scientist he is

Yeah, the whole time we've been solving this thing, I've been expecting Spence to show up and deduct the missing spots.

SivartAlappes wrote:The Bree Solution (that sounds REALLY important )
Objectives:
How to transform Bree from TRAIT: POSITIVE to TRAIT: NEGATIVE

Given Facts:
1) Bree's blood contains a special ribozyme mutated and unique only to her
2) The gene for said ribozyme has a regular hyper mutation that changes with every generation
3) A non-functioning mutated ribozyme exists and manifests differently in every Hymn of One girl
4) This portion still functions but you cannot blend it because the complimentary strands of RNA won't combine

Theoretical Solution
1) Block the ribozyme in question by obtaining a sample of that same ribozyme in order to copy it
2) Create complimentary strand of RNA
3) Q.E.D. strand will bind to ribozyme and occlude its copy

Practical Solution
1) Obtain blood sample of Bree
2) Synthesize complimentary strand of RNA
3) Inject Bree with this complementary strand
4) Q.E.D. ribozymes blocked will be rendered defunctional

Intended Results
1) Once synthesized and injected into Bree she'll become trait negative
2) Additional consequences (if any) - TBD

______ Reference Points
The steps concerning ribozyme function
RNAse P related -tRNA cleavage
Splicosome related - intron/exon splicing
______related - telomere synthesis
GlmS ribozyme related - fructose 6-phosphate pathway

DANG I totally just did WAY more work than I needed to... Before Reverence Points is "Bree Solution"

Edit: And I'm willing to bet, though this is just an educated guess, that the black before "related - telomere synthesis" is something having to do with DNA replication, such as "replication" or something, since that's what telomeres are involved in.

Heres my update:

The Bree Solution (that sounds REALLY important )
Objectives:
How to transform Bree from TRAIT: POSITIVE to TRAIT: NEGATIVE

Given Facts:
1) Bree's blood contains a special ribozyme mutated and unique only to her.
2) The gene for said ribozyme has a regular hyper mutation that changes with every generation.
3) A non-functioning mutated (?) ribozyme exists and manifests differently in every Hymn of One girl.
4) This portion still functions but you cannot block it because the complimentary strands of RNA won't copy.

Theoretical Solution
1) Block the ribozyme in question by obtaining a sample of that same ribozyme in order to copy it.
2) Create complimentary strand of RNA.
3) Q.E.D. strand will bind to ribozyme and occlude its activity (?).

Practical Solution
1) Obtain blood sample of Bree.
2) Synthesize complimentary strand of RNA
3) Inject Bree with this complementary strand.
4) Q.E.D. ribozymes blocked will be rendered ineffectual.

Intended Results
1) Once synthesized and injected into Bree she'll become trait negative
2) Additional consequences (if any) - TBD

______ Reference Points
The steps concerning ribozyme function
RNAse P related -tRNA cleavage
Splicosome related - intron/exon splicing
Hammerhead or Telomerase(?) related - telomere synthesis
GlmS ribozyme related - fructose 6-phosphate pathway

Samara wrote:

the solution has been posted to spencer.

Except that I think some of us disagree with a couple of the words in that solution.

a word here and there wont harm anything. what i am saying is that the foundation is there. spencer should take it and run with it.

and some things others post dont make much sense

kellylen wrote:

Samara wrote:

the solution has been posted to spencer.

Except that I think some of us disagree with a couple of the words in that solution.

a word here and there wont harm anything. what i am saying is that the foundation is there. spencer should take it and run with it.

and some things others post dont make much sense

Heres my update:

The Bree Solution (that sounds REALLY important )
Objectives:
How to transform Bree from TRAIT: POSITIVE to TRAIT: NEGATIVE

Given Facts:
1) Bree's blood contains a special ribozyme mutated and unique only to her.
2) The gene for said ribozyme has a regular hyper mutation that changes with every generation.
3) A non-functioning mutated (?) ribozyme exists and manifests differently in every Hymn of One girl.
4) This portion still functions but you cannot block it because the complimentary strands of RNA won't copy.

Theoretical Solution
1) Block the ribozyme in question by obtaining a sample of that same ribozyme in order to copy it.
2) Create complimentary strand of RNA.
3) Q.E.D. strand will bind to ribozyme and occlude its activity (?).

Practical Solution
1) Obtain blood sample of Bree.
2) Synthesize complimentary strand of RNA
3) Inject Bree with this complementary strand.
4) Q.E.D. ribozymes blocked will be rendered ineffectual.

Intended Results
1) Once synthesized and injected into Bree she'll become trait negative
2) Additional consequences (if any) - TBD

______ Reference Points
The steps concerning ribozyme function
RNAse P related -tRNA cleavage
Splicosome related - intron/exon splicing
Hammerhead or Telomerase(?) related - telomere synthesis
GlmS ribozyme related - fructose 6-phosphate pathway

What are your thoughts?

the ____________ reference points i thought could be retrivial