1B3D = Stromelysin?

archangelica · Post by **archangelica** » Sat Jun 30, 2007 10:36 am

I don't have time to spend on this, but I thought it was interesting:

Spencer says "First, B, Three, D" in his vid. I sincerely doubted that there was a clue in the vid, but check this out:

A search for "1B3D" yeilds results for Stromelysin catalytic domain.

Effective inhibitors of matrix metalloproteinases (MMPs), a family of connective tissue-degrading enzymes, could be useful for the treatment of diseases such as cancer, multiple sclerosis, and arthritis. Many of the known MMP inhibitors are derived from peptide substrates, with high potency in vitro but little selectivity among MMPs and poor bioavailability. We have discovered nonpeptidic MMP inhibitors with improved properties, and report here the crystal structures of human stromelysin-1 catalytic domain (SCD) complexed with four of these inhibitors. The structures were determined and refined at resolutions ranging from 1.64 to 2.0 A. Each inhibitor binds in the active site of SCD such that a bulky diphenyl piperidine moiety penetrates a deep, predominantly hydrophobic S'1 pocket. The active site structure of the SCD is similar in all four inhibitor complexes, but differs substantially from the peptide hydroxamate complex, which has a smaller side chain bound in the S'1 pocket. The largest differences occur in the loop forming the "top" of this pocket. The occupation of these nonpeptidic inhibitors in the S'1 pocket provides a structural basis to explain their selectivity among MMPs. An analysis of the unique binding mode predicts structural modifications to design improved MMP inhibitors.

his neutrogena site says he is into autocatalysis. I'm not learned enough in this area to make heads or tails of any of this, but I thought I'd throw it out to you guys.

ETA found a headline titled "Method of reducing stromelysin RNA via ribozymes."

Haha. I have no idea what it might mean, but there's another key word.

marlasinger · Post by **marlasinger** » Sat Jun 30, 2007 10:46 am

hmm...could it be that spencer is way smarter than we're giving him credit for? This is a tough lead, and not something that actually GIVES us much - but maybe he knows more about the Order than he's letting on, and knows that his messages should be encoded.

I'm not sure, I'd have to wait for the next vid to know.

suze900 · Post by **suze900** » Sat Jun 30, 2007 10:48 am

I'm picturing the Creators sitting back and going, "OMG WTF? did we MEAN to do that?" Or not.

Maybe I'm not giving them enough credit for planting way hidden cluez.

QUEEN_AKASHA2004 · Post by **QUEEN_AKASHA2004** » Sat Jun 30, 2007 10:56 am

suze900 wrote:I'm picturing the Creators sitting back and going, "OMG WTF? did we MEAN to do that?" Or not. Maybe I'm not giving them enough credit for planting way hidden cluez.

yah but then they will come to the forums and see we actually figured out some scientific thing with their mistake then they have to like make the store follow our findings

Opladybug · Post by **Opladybug** » Sat Jun 30, 2007 11:15 am

Actually some ppl were leaving out the one and came up with 3-aminopentanedioic acid instead...just thought I'd pass that on.

archangelica · Post by **archangelica** » Sat Jun 30, 2007 11:42 am

I mentioned this to my husband, and it got his attention. So I thought I'd let you know what he suggested.

1B3D specifically pointed to Stromelycin-1 in my search. I got a search result which mentioned "reducing stromelysin RNA via ribozymes."

Since I am educationally challenged when it comes to biology, I asked my husband what the implications of my google results might be.

He hypothesized that Stromelycin-1 is a catalytic gene. Suppose that stromelycin-1 is a catalyst for whatever makes a person Trait Positive. If the expression of stromelycin-1 can be suppressed, then there would be no catalyst for the Trait (which would lead to a Trait Negative status.) And apparantly this can be done by reducing the RNA via ribozymes.

anyway, I thought it was all very interesting, even though it gave me a terrible headache. I managed to escape college without studying biology, so please excuse my profuse ignorance on the subject.

ETA: this post is filled with errors, as was pointed out to me.

aura1298 · Post by **aura1298** » Sat Jun 30, 2007 11:43 am

there is a patent out there from 1998 that is this exact google search and not hard to find.

Method of reducing stromelysin RNA via ribozymes...

http://www.patentstorm.us/patents/57312 ... ption.html
------------------------------------------------------------------------------------
and here is a repeat of my research results...

HLA-D/Q/B-1
RR HLA-DR2-DQwl- 1 type
HLA-DQB1*0602-16140
Loci
a- prev
ab- prev
b- prev
EU7/EU8*: m170 mu+ {lgm: 22000 helena
EU18: bas.irs.scot.eng-2%
HLADRB-27
Ep
Nar
Celi d
Rhu
Maj hist incomt
Anim
End transmission.

are you seeing things yet?

stevemedigod · Post by **stevemedigod** » Sat Jun 30, 2007 12:07 pm

stromelysin is an enzyme that degrades other proteins. It's connection to RNA would be indirect. Likewise, I'm not finding any direct connection between 3-aminopentanedioic acid and RNA. So I'm confused.

uber_cast · Post by **uber_cast** » Sat Jun 30, 2007 12:14 pm

marlasinger wrote:hmm...could it be that spencer is way smarter than we're giving him credit for? This is a tough lead, and not something that actually GIVES us much - but maybe he knows more about the Order than he's letting on, and knows that his messages should be encoded.

I'm not sure, I'd have to wait for the next vid to know.

I believe you are right

archangelica · Post by **archangelica** » Sat Jun 30, 2007 12:17 pm

stevemedigod wrote:stromelysin is an enzyme that degrades other proteins. It's connection to RNA would be indirect. Likewise, I'm not finding any direct connection between 3-aminopentanedioic acid and RNA. So I'm confused.

I'm confused as well. What does "stromelycin gene expression" refer to, then? I'm absolutely not being snarky. I'm dangerously moronic when it comes to this subject.

ETA: If this thread is simply erroneous information having absolutely no relevence, then it needs to be locked quickly.

stevemedigod · Post by **stevemedigod** » Sat Jun 30, 2007 12:27 pm

"Stromelysin gene expression:"

Stromelysin is a protein. Like all proteins, it is synthesized when the gene (DNA) that encodes it is transcribed. That transcript is made out of RNA. so, a ribozyme designed to specifically cut the RNA that encodes stromelysin would be a method of reducing the amount of stromelysin made.

Stromelysin is a type of protein known as a protease. Proteases degrade other proteins. These are required for normal cell function and growth, but if too much is made in the wrong place, they can cause damage. This particular protease is important for regulating the matrix of proteins that surround cells.

This thread is not erroneous in that 1b3d is definitively the name of a protein structure file for stromelysin. What we have no idea of is whether this has any relevance to the actual message the Creators' intended.

archangelica · Post by **archangelica** » Sat Jun 30, 2007 12:42 pm

stevemedigod wrote:"Stromelysin gene expression:"

Thanks for explaining that in a way that I can actually understand fairly well.

This thread is not erroneous in that 1b3d is definitively the name of a protein structure file for stromelysin. What we have no idea of is whether this has any relevance to the actual message the Creators' intended.

Very true. For now, I think I'll enjoy the rest of my day and see if anyone more knowledgeable than I comes up with anything interesting. Thanks again for explaining.

TOSG · Post by **TOSG** » Sat Jun 30, 2007 1:17 pm

The ribozyme link is interesting.

I still think that it's probably a coincidence, though.

Stromelysin is a member of a class of proteins called matrix metalloproteinases. These proteins fulfill several crucial functions within the body, but can go haywire in many disease states, such as arthritis, emphysema, and metastatic cancer.

I don't think that a single member of this protein class would be biologically significant enough to hinge a big plot point on, if they're playing by "real life" scientific rules.

hella · Post by **hella** » Sat Jun 30, 2007 1:25 pm

who would that message be too anyways? maybe if he actually gives anything away he'll be in huge trouble so hes trying to secretly give clues? what was with the "go dad" line?

marlasinger · Post by **marlasinger** » Sat Jun 30, 2007 4:40 pm

the go dad line was about his father and his mistress - which apparently he didn't hear about until now. good times. but perhaps there's something more there?